Lymphomagenesis and Autoimmunization Caused by Reactions of T-Lymphocytes to Incompatible Structures of the Major Histocompatibility Complex: A Concept of Pathogenesis

摘要: The classic animal model for induction of graft-versus-host reactions (GVHRs) [1] is the parent → F1 hybrid system (Fig. 1). A variety different pathologic lesions can be induced in this system, as has recently been reviewed great detail [28, 54]. In present article, we shall focus on a pathogenetic concept lymphomagenesis and autoimmunization which was prompted one hand by experiments performed with GVH other important recent discoveries concerning physiologic T-lymphocytes to structures major histocompatibility complex (MHC). Since T-cell anti-MHC that are comparable those seen during GVHR may also occur an autologous (i.e., between cells same individual), it postulated they lead diseases semiallogeneic [49, This hypothesis will reexamined light findings obtained several groups investigators.