Genome-wide scans identify known and novel regions associated with prolificacy and reproduction traits in a sub-Saharan African indigenous sheep (Ovis aries).

摘要: Maximizing the number of offspring born per female is a key functionality trait in commercial- and/or subsistence-oriented livestock enterprises. Although closely associated with fertility and reproductive success, genetic control these traits remains poorly understood sub-Saharan Africa livestock. Using selection signature analysis performed on Ovine HD BeadChip data from prolific Bonga sheep Ethiopia, 41 candidate regions under were identified. The revealed one strong region chromosome X spanning BMP15, suggesting this to be primary prolificacy gene breed. also identified several genes not reported before but underlying reproduction other species. included SPOCK1 (age at first oestrus), GPR173 (mediator ovarian cyclicity), HB-EGF (signalling early pregnancy success) SMARCAL1 HMGN3a (regulate expression during embryogenesis). involved male FOXJ1 (sperm function successful fertilization) NME5 (spermatogenesis). We observed such as PKD2L2, MAGED1 KDM3B, which have been diverse both sexes results confirm complexity mechanisms while that sheep, possibly African indigenous partly BMP15 enhance are essential for fitness.