Molecular characterizations of glioblastoma, targeted therapy, and clinical results to date.

摘要: During the last decade, extensive multiplatform genome-wide analysis has yielded a wealth of knowledge regarding genetic and molecular makeup glioblastoma multiforme (GBM). These profiling studies support emerging view that GBM comprises group highly heterogeneous tumor types, each with its own distinct signatures. This heterogeneity complicates process defining reliable intertumor/intratumor biological states, which will ultimately be needed for classifying tumors designing effective customized therapies target resultant disease pathways. The increased understanding pathogenesis brought hope expectation such lead to better more rational directed toward specific targets. To date, however, these expectations have largely been unrealized. review discusses some principal epigenetic aberrations found in appear promising targeted now near future, it offers suggestions future directions concerning rather disappointing results clinical trials date.