Characterizing Tumors Using Metabolic Imaging: PET Imaging of Cellular Proliferation and Steroid Receptors

摘要: Treatment decisions in oncology are increasingly guided by information on the biologic characteristics of tumors. Currently, patient-specific tumor biology is obtained from analysis biopsy material. Positron emission tomography (PET) provides quantitative estimates regional biochemistry and receptor status can overcome sampling error difficulty performing serial studies inherent with biopsy. Imaging using glucose metabolism tracer, 2-deoxy-2-fluoro-D-glucose (FDG), has demonstrated PET's ability to guide therapy clinical oncology. In this review, we highlight PET approaches imaging two other aspects biology: cellular proliferation steroid receptors. We review biochemical processes underlying imaging, positron-emitting radiopharmaceuticals that have been developed, image-analysis considerations, date. This a basis for evaluating future developments these promising applications metabolic imaging.