Synthesis and biological evaluation of adamantane-based aminophenols as a novel class of antiplasmodial agents.
作者： Murugan Chinnapattu , Kulathu Iyer Sathiyanarayanan , Pravin S. Iyer
DOI: 10.1016/J.BMCL.2014.12.037
关键词:
摘要: A series of adamantane based aminophenol derivatives were synthesized and evaluated for their antiplasmodial activity in vitro against Plasmodium falciparum (Pf_NF54) resistant strain (Pf_K1). Herein, we report compounds resulting from this work that show excellent potency both strains. Additionally, displayed cytotoxicity selectivity index THP1 cell line had acceptable DMPK properties.
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