Mechanism of quasi-morphine withdrawal behaviour induced by methylxanthines
作者： Naeem M. Butt , Harry O.J. Collier , Nigel J. Cuthbert , David L. Francis , Sheikh A. Saeed
DOI: 10.1016/0014-2999(79)90462-X
关键词:
摘要: Of 7 phosphodiesterase inhibitors tested for ability to induce a quasi-morphine withdrawal syndrome (QMWS) in opiate-naive rats, five were effective dose-related way. These, descending order of potency, IBMX, ICI-63197, RO-201724, theophylline and caffeine. Their potencies inducing QMWS correlated significantly (P less than 0.05) with those inhibiting low Km cyclic AMP rat brain homogenate. There was no correlation GMP phosphodiesterase.
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