YBX1 regulates tumor growth via CDC25a pathway in human lung adenocarcinoma.

摘要: Y-box binding protein 1 (YBX1) is involved in the multi-tumor occurrence and development. However, regulation of YBX1 lung tumorigenesis underlying mechanisms, especially its relationship with CDC25a, was remains unclear. In this study, we analyzed expression clinical significance CDC25a adenocarcinoma identified their roles cancer growth. The retrospective analysis 116 patients indicated that positively correlated expression. Cox-regression showed only high-ranking TNM stage low were an independent risk factor prognosis enrolled patients. High or also observed cells compared HLF cells. ChIP assay demonstrated endogenous to promoter region. Overexpression exogenous up-regulated promoter-driven luciferase. By contrast, inhibition by siRNA markedly decreased capability A549 H322 Inhibition blocked cell cycle progression, suppressed proliferation induced apoptosis via pathway vitro. Moreover, a xenograft mouse model down-regulated YBX1, Ki67 cleaved caspase 3 tumor tissues mice. Collectively, these results demonstrate growth partly high YBX1/CDC25a predicts poor human adenocarcinoma.