Systemic hypertension in obstructive sleep apnea.

摘要: There is consistent epidemiological evidence that sleep disordered breathing and systemic arterial hypertension are deeply associated, being linked through a bidirectional complex interaction among multiple mechanisms including autonomic nervous system alterations, inflammation, hormonal hemodynamic components, alterations. However there several unanswered questions not only from pathophysiological perspective, but also regarding the effects of obstructive apnea (OSA) treatment on blood pressure values. At present, while many studies have supported possibility to obtain at least small reduction with OSA treatment, in particular hypertensive patients, large trials clearly confirmed significant anti-hypertensive effect, nor beneficial effect this intervention cardiovascular endpoints mortality. Aim present review article address relationship between light latest field. Moreover we will discuss research topics which need be investigated future, order better clarify still pending issues aim obtaining an early diagnosis, more suitable phenotyping comorbidities, strategies improve patients’ compliance adherence treatment.