Stress and glucocorticoid footprints in the brain—The path from depression to Alzheimer's disease
作者： I. Sotiropoulos , J.J. Cerqueira , C. Catania , A. Takashima , N. Sousa
DOI: 10.1016/J.NEUBIOREV.2008.05.007
关键词:
摘要: Increasingly, stress is recognized as a trigger of depressive episodes and recent evidence suggests causal role in the onset progression Alzheimer's disease (AD) pathology. Besides aging, sex an important determinant prevalence rates for both AD mood disorders. In light meta-analysis indicating that depressed subjects have higher likelihood developing AD, key message this article will be depression are stress-related disorders may represent continuum should receive more attention future neurobiological studies. Accordingly, review considers some cellular mechanisms involved regulating transition threshold. addition, it highlights importance addressing question how aging interplay with to influence cognition, bias towards consideration neuroplastic events particular brain regions, basis
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