Beneficial Effect of Serotonin 5-HT2-Receptor Antagonism on Renal Blood Flow Autoregulation in Cyclosporin-Treated Rats
作者： Johan Van De Voorde , Marleen Verbeke , Leo De Ridder , Norbert Lameire
DOI: 10.1681/ASN.V10128
关键词:
摘要: Renal blood flow (RBF) autoregulation reappears in postischemic rat kidneys during serotonin (5-HT2) antagonism. The aim of the present study was to analyze whether 5-HT2 antagonism can ameliorate impaired RBF rats treated with 20 mg/kg per d cyclosporin A 10 d. Autoregulation assessed stepwise lowering renal perfusion pressure from 110 70 mmHg by gradual compression aorta. lost A-treated rats. During administration antagonist ritanserin (0.6 intravenous bolus, followed 1.2 h infusion 1 h), acutely reappeared. Intrarenal bolus injections a selective 5-HT2-agonist, 2,5 dimethoxy-4-iodoamphetamine hydrochloride, elicited significantly stronger vasocontraction than control This finding also observed after nitric oxide-synthase blockade. These results (1) show importance 5-HT2-receptor-mediated vasoconstriction suppression vasodilatory experimental A-induced dysfunction and (2) demonstrate that complete loss is not due damage vascular smooth muscle cells.
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