The Role of the Endothelium in the Cardiovascular Response to Serotonin

摘要: Serotonin causes constriction of the vascular smooth muscle cells and platelet aggregation mainly through activation 5-HT2-serotonergic receptors. The vasoconstrictor effects serotonin can be counteracted by prejunctional inhibition adrenergic neurotransmission predominantly release endothelium derived relaxing factor. These monoamine are caused 5-HT1-like serotonergic Endothelium factor also prevents adhesion to wall. When is dysfunctional, as case in atherosclerosis or after has recovered from an injury, cannot induce liberation but will cause contracting As a result vasoconstriction occur. may increase viscosity blood action on red white cells, which further impairment flow. At same time growth factor, released aggregating platelets proliferation participates progression atherosclerosis.