Multimodal Prediction of Dementia with up to 10 Years Follow Up: The Gothenburg MCI Study

摘要: Background: Neuropsychological tests, CSF A42, T-tau, P-tau181, hippocampal volume, and white matter lesions have been shown to predict conversion dementia in patients with mild cognitive impairment (MCI). Objective: To examine the predictive value of combinations these markers if absence pathological provides a lasting reduction rates. Methods: The Gothenburg MCI study is clinically based study. Seventy-three were included present sub-study followed for maximum ten years. Thirty-four converted (18 AD) 39 remained stable. At inclusion, classified into positive or negative risk groups according results from neuropsychological testing (Rey auditory verbal learning test, Boston naming Trail making test B), biomarkers (amyloid 42, P-tau181) MRI scans (hippocampal lesions). Results: B (TMT-B) was best single predictor prediction (AUC 0.89, HR 25), T-tau AD 0.97, 41). combination volume TMT-B (HR 37). Conclusion: markers, predicted general dementia. provided long-time protection