Are we ready to move away from nature? The rapamycin story

摘要: We have seen it all in cancer treatment. work with tree extracts, marine sponges, viruses, soil and many other things. Nature has giving us the tools to treat this threatening disease will continue do so if we an open mind are willing learn; gained extensive knowledge from rapamycin story. It started a far-far away Island (Easter Island) bacteria identification of microcyclic antibiotic antifungal properties. Twenty years later. know (or think know) target (TOR), TOR complexes, upstream downstream effectors, elements that activate or inhibit pathway, start seeing promising effects targeting mammalian (mTOR) not only but also conditions such as inflammation aging. mother compound approved for graft rejection, rapamycin-coated arterial stents. three analogs improved pharmacological properties usethemtotreatvariousmalignancies[1–4]. patients benefiting treatment rapalogs doing remarkably well prolonged time almost no change quality life. very familiar toxicity profile believe they safe compatible use [5].