Aging and cancer: can mTOR inhibitors kill two birds with one drug?

摘要: The main risk factor for a number of diseases, including cancer, is aging. By delaying the effects aging, many years research indicate that diseases associated with aging are reduced by prolongevity interventions such as reductions in caloric intake and mice genetically deficient growth factors. Although studies dietary restriction have been highly informative regarding process, they both unrealistic human application. Recent preclinical results pharmacological agent (rapamycin) provide proof-of-concept an approach feasible populations. Exactly how rapamycin works to extend lifespan under increasingly intense investigation. In addition, these underscore critical role intracellular target (TOR) plays one deepest mysteries life, How age-associated interface TOR its signaling systems, tremendous opportunities discovery new drugs most exciting areas currently being conducted this era research.