The effects of botulinum toxin type A on muscle blood perfusion and metabolism.

摘要: Background: Botulinum toxin type A is approved by the U.S. Food and Drug Administration for treatment of facial rhytides. However, complete spectrum action botulinum has not yet been completely defined. Little known about metabolism muscle after injection. This information may give insight into additional effects have on muscle. The authors assessed influence using dynamic investigative techniques. Methods: Twenty New Zealand White rabbits were divided control, paralysis, sham groups. Masseter paralysis was achieved with A. Dynamic computed tomographic positron emission scans obtained. blood flow, volume, permeability surface, mean transit time glucose uptake measured. Results: Eighteen animals completed study. perfusion showed consistent results across all parameters. Blood surface significantly increased at weeks 4 8 paralyzed side. Mean week decreased Positron that injected muscles in group tended to compared untreated muscles. Conclusions: injection increases parameters a transient period. increase similar duration interval A-induced paralysis. These changes identified fashion represent calcitonin gene-related peptide release.