Characterization of GIP(1–30) and GIP(1–42) as stimulators of proinsulin gene transcription

作者: Hans-Christoph Fehmann , Burkhard Göke

DOI: 10.1016/0196-9781(95)00090-7

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摘要: Originally characterized in terms of its gastric acid inhibitory properties, GIP (gastric polypeptide) expressed the upper small intestine, was subsequently shown to exert strong glucose-dependent insulin-releasing properties. This action is generally attributed GIP(1-42) and, so far, no evidence for contribution other relevant forms exists. In this study, we compared effects and C-terminally truncated GIP(1-30) on cAMP production proinsulin gene transcription at clonal insulin-secreting cell lines (RIN 1046-38, beta TC-3). Both peptides were equally potent stimulators generation both lines. Insulin release from RIN 1046-38 cells stimulated by identical. B-cell expression equipotently. not only enhances insulin secretion but also therefore, it a true insulinotropic hormone.

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