Reversal of islet GIP receptor down-regulation and resistance to GIP by reducing hyperglycemia in the Zucker rat
作者： Shalea Piteau , Amy Olver , Su-Jin Kim , Kyle Winter , John Andrew Pospisilik
DOI: 10.1016/J.BBRC.2007.08.115
关键词:
摘要: In type 2 diabetes (T2DM) beta-cell responsiveness to glucose-dependent insulinotropic polypeptide (GIP) is reduced. a model of T2DM, the VDF Zucker rat, GIP receptor mRNA and protein levels were shown be down-regulated. Possible restoration in rats by reducing hyperglycemia has been examined. ZDF with extreme demonstrated greater islet down-regulation (94.3+/-3.8%) than ZF (48.8+/-22.8%). returned 83.0+/-17.9% lean following normalization phlorizin treatment pancreas perfusions markedly improved responsiveness. Treatment DP IV inhibitor (P32/98) resulted glucose tolerance restored sensitivity isolated pancreata. These findings support proposal that rodent T2DM secondary chronic glycemia can restore sensitivity.
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Y.-T. Zhou, M. Shimabukuro, M.-Y. Wang, Y. Lee, M. Higa, J. L. Milburn, C. B. Newgard, R. H. Unger, Role of peroxisome proliferator-activated receptor α in disease of pancreatic β cells Proceedings of the National Academy of Sciences of the United States of America. ,vol. 95, pp. 8898- 8903 ,(1998) , 10.1073/PNAS.95.15.8898
Jan A. Ehses, Vanbric R. Casilla, Tim Doty, J. Andrew Pospisilik, Kyle D. Winter, Hans-Ulrich Demuth, Raymond A. Pederson, Christopher H. S. McIntosh, Glucose-Dependent Insulinotropic Polypeptide Promotes β-(INS-1) Cell Survival via Cyclic Adenosine Monophosphate-Mediated Caspase-3 Inhibition and Regulation of p38 Mitogen-Activated Protein Kinase Endocrinology. ,vol. 144, pp. 4433- 4445 ,(2003) , 10.1210/EN.2002-0068
Francis C. Lynn, Stephen A. Thompson, J. Andrew Pospisilik, Jan A. Ehses, Simon A. Hinke, Nathalie Pamir, Christopher H. S. McIntosh, Raymond A. Pederson, A novel pathway for regulation of glucose-dependent insulinotropic polypeptide (GIP) receptor expression in beta cells. The FASEB Journal. ,vol. 17, pp. 91- 93 ,(2003) , 10.1096/FJ.02-0243FJE
M A Nauck, M M Heimesaat, C Orskov, J J Holst, R Ebert, W Creutzfeldt, Preserved incretin activity of glucagon-like peptide 1 [7-36 amide] but not of synthetic human gastric inhibitory polypeptide in patients with type-2 diabetes mellitus. Journal of Clinical Investigation. ,vol. 91, pp. 301- 307 ,(1993) , 10.1172/JCI116186
Andrea Trümper, Katja Trümper, Heidi Trusheim, Rudolf Arnold, Burkhard Göke, Dieter Hörsch, Glucose-Dependent Insulinotropic Polypeptide Is a Growth Factor for β (INS-1) Cells by Pleiotropic Signaling Molecular Endocrinology. ,vol. 15, pp. 1559- 1570 ,(2001) , 10.1210/MEND.15.9.0688
Hans-Christoph Fehmann, Burkhard Göke, Characterization of GIP(1–30) and GIP(1–42) as stimulators of proinsulin gene transcription Peptides. ,vol. 16, pp. 1149- 1152 ,(1995) , 10.1016/0196-9781(95)00090-7
Joel R. L. Ehrenkranz, Norman G. Lewis, C. Ronald Kahn, Jesse Roth, Phlorizin: a review. Diabetes-metabolism Research and Reviews. ,vol. 21, pp. 31- 38 ,(2005) , 10.1002/DMRR.532
Raphaël Roduit, Johane Morin, Frédéric Massé, Laura Segall, Enrique Roche, Christopher B. Newgard, Françoise Assimacopoulos-Jeannet, Marc Prentki, Glucose Down-regulates the Expression of the Peroxisome Proliferator-activated Receptor-α Gene in the Pancreatic β-Cell * Journal of Biological Chemistry. ,vol. 275, pp. 35799- 35806 ,(2000) , 10.1074/JBC.M006001200
K. Almind, L. Ambye, S. A. Urhammer, T. Hansen, S. M. Echwald, J. J. Holst, J. Gromada, B. Thorens, O. Pedersen, Discovery of amino acid variants in the human glucose-dependent insulinotropic polypeptide (GIP) receptor: the impact on the pancreatic beta cell responses and functional expression studies in Chinese hamster fibroblast cells Diabetologia. ,vol. 41, pp. 1194- 1198 ,(1998) , 10.1007/S001250051051
T. Vilsbøll, F. K. Knop, T. Krarup, A. Johansen, S. Madsbad, S. Larsen, T. Hansen, O. Pedersen, J. J. Holst, The pathophysiology of diabetes involves a defective amplification of the late-phase insulin response to glucose by glucose-dependent insulinotropic polypeptide-regardless of etiology and phenotype The Journal of Clinical Endocrinology and Metabolism. ,vol. 88, pp. 4897- 4903 ,(2003) , 10.1210/JC.2003-030738