Analysis of pooled DNA samples on high density arrays without prior knowledge of differential hybridization rates
作者： Stuart Macgregor , Peter M Visscher , Grant Montgomery
DOI: 10.1093/NAR/GKL136
关键词:
摘要: Array based DNA pooling techniques facilitate genome-wide scale genotyping of large samples. We describe a structured analysis method for pooled data using internal replication information in sets. The takes advantage from single nucleotide polymorphisms (SNPs) typed parallel on high density array to construct test statistic with desirable statistical properties. utilize general linear model appropriately account the multiple measurements available data. does not require use additional arrays estimation unequal hybridization rates and hence scales readily accommodate several hundred thousand SNPs. Tests differences between cases controls can be conducted very few arrays. demonstrate 384 endometriosis controls,
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