Racial and Ethnic Differences in Individuals with Sporadic Creutzfeldt-Jakob Disease in the United States of America

摘要: Background Little is known about racial and ethnic differences in individuals with sporadic Creutzfeldt-Jakob disease (sCJD). The authors sought to examine potential clinical, diagnostic, genetic, neuropathological sCJD patients of different races/ethnicities. Methodology/Principal Findings A retrospective study 116 definite probable cases from Johns Hopkins the Department Veterans Affairs Healthcare Systems was conducted that examined demographic, characteristics among racial/ethnic groups. Age at onset differed Non-Hispanic Whites had a significantly older age compared other groups (65 vs. 60, p = 0.036). Non-Whites were accurately diagnosed more rapidly than (p 0.008) non-Hispanic likely have normal appearing basal ganglia on brain magnetic resonance imaging (MRI) minorities 0.02). also undergo post-mortem evaluation non-Whites 0.02). Conclusions/Significance Racial/ethnic affected by demonstrated onset, time correct diagnosis, clinical presentation, diagnostic test results. autopsy non-Whites. These results implications regards case ascertainment, surveillance possibly human prion diseases.