Modulation of antagonist binding to serotonin1A receptors from bovine hippocampus by metal ions.

作者: K. G. Harikumar , Amitabha Chattopadhyay

DOI: 10.1023/A:1013811221577

关键词:

摘要: 1. The serotonin1A(5-HT1A) receptors are members of a superfamily seven transmembrane domain that couple to G-proteins. They appear be involved in various behavioral and cognitive functions. Although specific 5-HT1Aagonists have been discovered more than decade back, the development selective 5-HT1Aantagonists has achieved only recently.

参考文章(36)
Karin E. Limburg, Mary Ann Moran, Synthesis and Evaluation Springer, New York, NY. pp. 155- 172 ,(1986) , 10.1007/978-1-4612-4874-3_6
Catherine D. Strader, Tung Ming Fong, Michael P. Grazlano, Michael R. Tota, The family of G-protein-coupled receptors. The FASEB Journal. ,vol. 9, pp. 745- 754 ,(1995) , 10.1096/FASEBJ.9.9.7601339
Beatriz A. Rocha, Kimberly Scearce-Levie, José J. Lucas, Noboru Hiroi, Nathalie Castanon, John C. Crabbe, Eric J. Nestler, René Hen, Increased vulnerability to cocaine in mice lacking the serotonin-1B receptor. Nature. ,vol. 393, pp. 175- 178 ,(1998) , 10.1038/30259
Mu Mu, H. F. Kung, Zhi-Ping Zhuang, Mei-Ping Kung, D. Frederick, 4-(2'-Methoxy-phenyl)-1-[2'-(n-2"-pyridinyl)-p-iodobenzamido]-ethyl- piperazine ([125I]p-MPPI) as a new selective radioligand of serotonin-1A sites in rat brain: in vitro binding and autoradiographic studies. Journal of Pharmacology and Experimental Therapeutics. ,vol. 272, pp. 429- 437 ,(1995)
B. L. Jacobs, E. C. Azmitia, Structure and function of the brain serotonin system Physiological Reviews. ,vol. 72, pp. 165- 229 ,(1992) , 10.1152/PHYSREV.1992.72.1.165
Raymond Mongeau, Sharon A. Welner, Rémi Quirion, Barbara E. Suranyi-Cadotte, Further evidence for differential affinity states of the serotonin1A receptor in rat hippocampus. Brain Research. ,vol. 590, pp. 229- 238 ,(1992) , 10.1016/0006-8993(92)91100-S
Stephen J. Peroutka, 5‐Hydroxytryptamine Receptors Journal of Neurochemistry. ,vol. 60, pp. 408- 416 ,(1993) , 10.1111/J.1471-4159.1993.TB03166.X
Richard A. Bond, Paul Leff, T.David Johnson, Carmelo A. Milano, Howard A. Rockman, Thomas R. McMinn, Subramaniam Apparsundaram, Michael F. Hyek, Terry P. Kenakin, Lee F. Allen, Robert J. Lefkowitz, Physiological effects of inverse agonists in transgenic mice with myocardial overexpression of the β2-adrenoceptor Nature. ,vol. 374, pp. 272- 276 ,(1995) , 10.1038/374272A0
H. Gozlan, S. El Mestikawy, L. Pichat, J. Glowinski, M. Hamon, Identification of presynaptic serotonin autoreceptors using a new ligand: 3H-PAT. Nature. ,vol. 305, pp. 140- 142 ,(1983) , 10.1038/305140A0
A. Chattopadhyay, R. Rukmini, S. Mukherjee, Photophysics of a neurotransmitter: ionization and spectroscopic properties of serotonin Biophysical Journal. ,vol. 71, pp. 1952- 1960 ,(1996) , 10.1016/S0006-3495(96)79393-1