Defect of an Early Event of Glucose Metabolism in Skeletal Muscle of the Male Otsuka Long-Evans Tokushima Fatty (OLETF) Rat, a Non-Insulin- Dependent Diabetes Mellitus (NIDDM) Model
作者： Takashi Sato , Kiyohiko Magata , Nobuyuki Koga , Yasuhide Mitsumoto
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摘要: Otsuka Long-Evans Tokushima Fatty (OLETF) rats showed that the distribution of plasma membrane content insulin-regulated glucose transporter in skeletal muscle was reminiscent human non-insulin-dependent diabetes mellitus (NIDDM). To obtain more information on cellular mechanisms insulin resistance, hexokinase activities were measured OLETF rats. The results activity type II enzyme diabetic significantly decreased (P<0.05) compared with (LETO) control No significant differences I observed between these Western blot analysis protein also lower than LETO (P<0.05). After stimulation, intramuscular 6-phosphate, which regulates glycogen synthesis muscle, (P<0.01). However, synthase activityin vitroand lactate concentration did not show differences. These suggest G6P is as a result an impaired early event metabolism, indicating molecular defects are similar to those NIDDM patients.
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