Abnormality in fibre type distribution of soleus and plantaris muscles in non-obese diabetic Goto-Kakizaki rats.
作者： Koichiro Yasuda , Waka Nishikawa , Nobumasa Iwanaka , Eitaro Nakamura , Yutaka Seino
DOI: 10.1046/J.1440-1681.2002.03757.X
关键词:
摘要: 1. Fibre type distributions of the slow soleus and fast plantaris muscles were investigated in 5-, 9- 20-week-old male Goto-Kakizaki (GK) rats, as an animal model non-obese diabetes, compared with those age-matched non-diabetic Wistar rats. 2. Bodyweight both muscle weights lower GK rats than regardless age. In addition, relative per bodyweight 3. muscle, a higher percentage I fibres IIA observed 5- 9-week-old there no 4. differences fibre distribution 5-week-old However, IIB 5. These results indicate that decreased high-oxidative (e.g. muscle) diabetic animals is concerned impairment insulin sensitivity glucose metabolism not related to bodyweight.
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