N-3 fatty acids and cardiovascular events after myocardial infarction.

摘要: Background Results from prospective cohort studies and randomized, controlled trials have provided evidence of a protective effect n−3 fatty acids against cardiovascular diseases. We examined the marine eicosapentaenoic acid (EPA) docosahexaenoic (DHA) plant-derived alpha-linolenic (ALA) on rate events among patients who had myocardial infarction. Methods In multicenter, double-blind, placebo-controlled trial, we randomly assigned 4837 patients, 60 through 80 years age (78% men), infarction were receiving state-of-the-art antihypertensive, antithrombotic, lipid-modifying therapy to receive for 40 months one four trial margarines: margarine supplemented with combination EPA DHA (with targeted additional daily intake 400 mg EPA–DHA), ALA 2 g ALA), EPA–DHA an...