Stem cells: good, bad and reformable.

作者: Viktor Janzen , David T. Scadden

DOI: 10.1038/441418B

关键词:

摘要: The ability of stem cells to continuously supply vast numbers is magnificent, but it can be devastating if runs amok, as in some tumours. So what makes a normal cell turn bad, and redeemed?

参考文章(12)
Dos D Sarbassov, Siraj M Ali, Shomit Sengupta, Joon-Ho Sheen, Peggy P Hsu, Alex F Bagley, Andrew L Markhard, David M Sabatini, None, Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB. Molecular Cell. ,vol. 22, pp. 159- 168 ,(2006) , 10.1016/J.MOLCEL.2006.03.029
Luís Borda-de-Água, Stephen P. Hubbell, The Unified Neutral Theory of Biodiversity and Biogeography ,(2001)
Jiwang Zhang, Justin C. Grindley, Tong Yin, Sachintha Jayasinghe, Xi C. He, Jason T. Ross, Jeffrey S. Haug, Dawn Rupp, Kimberly S. Porter-Westpfahl, Leanne M. Wiedemann, Hong Wu, Linheng Li, PTEN maintains haematopoietic stem cells and acts in lineage choice and leukaemia prevention Nature. ,vol. 441, pp. 518- 522 ,(2006) , 10.1038/NATURE04747
Matthias Groszer, Rebecca Erickson, Deirdre D Scripture-Adams, Ralf Lesche, Andreas Trumpp, Jerome A Zack, Harley I Kornblum, Xin Liu, Hong Wu, Negative Regulation of Neural Stem/Progenitor Cell Proliferation by the Pten Tumor Suppressor Gene in Vivo Science. ,vol. 294, pp. 2186- 2189 ,(2001) , 10.1126/SCIENCE.1065518
Joan Seoane, Hong-Van Le, Lijian Shen, Stewart A Anderson, Joan Massagué, Integration of Smad and forkhead pathways in the control of neuroepithelial and glioblastoma cell proliferation. Cell. ,vol. 117, pp. 211- 223 ,(2004) , 10.1016/S0092-8674(04)00298-3
Tao Cheng, Neil Rodrigues, Hongmei Shen, Yong-guang Yang, David Dombkowski, Megan Sykes, David T Scadden, Hematopoietic stem cell quiescence maintained by p21cip1/waf1. Science. ,vol. 287, pp. 1804- 1808 ,(2000) , 10.1126/SCIENCE.287.5459.1804
Ömer H. Yilmaz, Riccardo Valdez, Brian K. Theisen, Wei Guo, David O. Ferguson, Hong Wu, Sean J. Morrison, Pten dependence distinguishes haematopoietic stem cells from leukaemia-initiating cells Nature. ,vol. 441, pp. 475- 482 ,(2006) , 10.1038/NATURE04703
M. Groszer, R. Erickson, D. D. Scripture-Adams, J. D. Dougherty, J. Le Belle, J. A. Zack, D. H. Geschwind, X. Liu, H. I. Kornblum, H. Wu, PTEN negatively regulates neural stem cell self-renewal by modulating G0-G1 cell cycle entry Proceedings of the National Academy of Sciences of the United States of America. ,vol. 103, pp. 111- 116 ,(2006) , 10.1073/PNAS.0509939103