The effect of variation in molecular weight on the antigenicity of dextran in man.

作者: Elvin A. Kabat , Ada E. Bezer

DOI: 10.1016/0003-9861(58)90354-0

关键词:

摘要: Abstract The capacity of a series dextran fractions graded molecular weight to stimulate antibody formation in man upon injection 1 mg. was investigated. A significant drop elicit found with average 51,300 or below. precipitating antibodies the were generally similar those produced native as determined by quantitative precipitin and oligosaccharide inhibition studies. Wheal erythema reactions obtained when circulating levels above 7–8 μg. N/ml.

参考文章(15)
Deborah Berg, Elvin A. Kabat, Dextran—An Antigen in Man Journal of Immunology. ,vol. 70, pp. 514- 532 ,(1953)
EdwardJ. Hehre, With a note by Frederic R. Senti and Nison N. Hellman, Natural synthesis of low molecular weight (clinical type) dextran by a Streptococcus strain. Journal of Biological Chemistry. ,vol. 222, pp. 739- 750 ,(1956) , 10.1016/S0021-9258(20)89932-3
ANDERS GRÖNWALL, BJÖRN INGELMAN, Untersuchungen über Dextran und sein Ver-halten bei parentersler Zufuhr. I. Acta Physiologica Scandinavica. ,vol. 7, pp. 97- 107 ,(1944) , 10.1111/J.1748-1716.1944.TB03016.X
N. N. Hellman, H. M. Tsuchiya, S. P. Rogovin, B. L. Lamberts, Robert Tobin, C. A. Glass, C. S. Stringer, R. W. Jackson, F. R. Senti, Controlled enzymatic synthesis of dextran Industrial & Engineering Chemistry. ,vol. 47, pp. 1593- 1598 ,(1954) , 10.1021/IE50548A038
M. HEIDELBERGER, C. F. C. MACPHERSON, QUANTITATIVE MICRO-ESTIMATION OF ANTIBODIES IN THE SERA OF MAN AND OTHER ANIMALS. Science. ,vol. 97, pp. 405- 406 ,(1943) , 10.1126/SCIENCE.97.2522.405
Peter Z. Allen, Elvin A. Kabat, Studies on the capacity of some polysaccharides to elicit antibody formation in man. Journal of Experimental Medicine. ,vol. 105, pp. 383- 394 ,(1957) , 10.1084/JEM.105.5.383
Elvin A. Kabat, Size and heterogeneity of the combining sites on an antibody molecule Journal of Cellular and Comparative Physiology. ,vol. 50, pp. 79- 102 ,(1957) , 10.1002/JCP.1030500406
Elvin A. Kabat, Heterogeneity in Extent of the Combining Regions of Human Antidextran Journal of Immunology. ,vol. 77, pp. 377- 385 ,(1956)
Elvin A. Kabat, Gerard M. Turino, Arthur B. Tarrow, Paul H. Maurer, Studies on the Immunochemical Basis of Allergic Reactions to Dextran in Man12 Journal of Clinical Investigation. ,vol. 36, pp. 1160- 1170 ,(1957) , 10.1172/JCI103512
Elvin A. Kabat, Deborah Berg, PRODUCTION OF PRECIPITINS AND CUTANEOUS SENSITIVITY IN MAN BY INJECTION OF SMALL AMOUNTS OF DEXTRAN Annals of the New York Academy of Sciences. ,vol. 55, pp. 471- 475 ,(1952) , 10.1111/J.1749-6632.1952.TB26563.X