Impact of gestational low protein diet and postnatal bisphenol A exposure on chemically induced mammary carcinogenesis in female offspring rats.

摘要: This study evaluated the effect of gestational low protein diet (LPD) and/or postnatal bisphenol A (BPA) exposure on mammary gland development and carcinogenesis in female offspring. Pregnant Sprague-Dawley rats were fed a normal (NPD, 17% protein) or LPD (6% protein). At weaning, offspring distributed four groups LPD, NPD + BPA, BPA) received vehicle BPA drinking water (0.1%), during day (PND) 21 to 51. On PND 51, some euthanized single dose 7,12-dimethylbenzoanthracene (DMBA, 30 mg/kg, i.g.) 250. neither nor exposure, individually combination, significantly altered tree, mean number terminal structures estrogen receptor beta (ER-β), proliferating cell nuclear antigen (PCNA) caspase-3 expression tissue. significant reduction epithelial area (%) was observed both increase ER-α detected only group. In group fat pad cells positive for progesterone (PR). 250, that presented lower latency higher tumor incidence multiplicity more aggressive tumors. These findings suggest associated with is able induce morphological changes susceptibility carcinogenesis.