Metabolomic-Based Strategies for Anti-Parasite Drug Discovery

摘要: Metabolomics-based studies are proving of great utility in the analysis modes action (MOAs) and resistance mechanisms drugs parasitic protozoa. They have helped to determine MOA eflornithine, half gold standard combination therapy use against human African trypanosomiasis (HAT), as well mechanism this drug. In Leishmania, metabolomics has also given insight into miltefosine, an alkylphospholipid. Several on antimony Leishmania been conducted, analyzing metabolic content resistant lines, offering clues class drugs. A study chloroquine Plasmodium falciparum combined techniques with other genetic proteomic offer new role PfCRT protein. The a group halogenated pyrimidines Trypanosoma brucei recently elucidated. Effective are, care must be taken design implementation these experiments, ensure resulting data meaningful. This review outlines steps required conduct experiment provide overview metabolomics-based drug research protozoa date.