Ginseng polysaccharide serves as a potential radiosensitizer through inducing apoptosis and autophagy in the treatment of osteosarcoma.

摘要: Abstract Recent studies have confirmed that the combined use of anti-cancer drugs with ionizing radiation (IR) could improve sensitivity osteosarcoma (OS) cells. Therefore, it is necessary to identify potential effective for enhancement IR-radiosensitivity. In current study, we found 20, 10, 5, and 1 μM ginseng polysaccharide (GPS) significantly suppressed MG-63 cell viability or without γ-ray in a dose- time-dependent manner. Strikingly, 20 μM GPS 5 Gy treatment colony formation capacity by nearly 13.75∼fold compared IR alone. Our results showed markedly induce early apoptosis autophagy A higher drug concentration greater exposure dose were directly associated more Western blot analysis decreased phosphorylation p38 AKT as well protein expression Bax cleaved-caspase3. summary, inhibited proliferation increased autophagic death OS cells, indicating may be auxiliary improving patients.