Anaemia in Heart Failure: A Prospective Evaluation of Clinical Outcome in a Community Population

作者: Tanya Stewart , Jane Freeman , Jessica Stewart , Anne Sullivan , Christopher Ward

DOI: 10.1016/J.HLC.2010.08.004

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摘要: Introduction Although anaemia is associated with an adverse prognosis in congestive heart failure (HF), the cause of and its relationship to non-cardiac cardiac complications needs be better defined, particularly a general community population. Methods Clinical data were collected prospectively from 959 patients hospitalised HF. Results Thirty-eight percent ( n =369) had (Hb p =0.05), LVEF>40% (49 vs 39%, =0.004), less likely receive ACE inhibitors (72 78%, =0.04). At 12 months, anaemic higher HF readmission rates (22.4 15.7%, =0.01), more multiple non-HF readmissions (12.4 6.3%, =0.001) mortality (16.4% 10.5%, =0.01). Conclusion Anaemia common (38%) HF, increased readmissions, mortality. A haematinic deficiency was identified 15.5% patients. common, multifactorial, but potentially treatable outcome

参考文章(20)
Hessel F. Groenveld, James L. Januzzi, Kevin Damman, Jan van Wijngaarden, Hans L. Hillege, Dirk J. van Veldhuisen, Peter van der Meer, Anemia and Mortality in Heart Failure Patients: A Systematic Review and Meta-Analysis Journal of the American College of Cardiology. ,vol. 52, pp. 818- 827 ,(2008) , 10.1016/J.JACC.2008.04.061
Paul C Hébert, George Wells, Morris A Blajchman, John Marshall, Claudio Martin, Giuseppe Pagliarello, Martin Tweeddale, Irwin Schweitzer, Elizabeth Yetisir, Transfusion Requirements in Critical Care Investigators for the Canadian Critical Care Trials Group, A multicenter, randomized, controlled clinical trial of transfusion requirements in critical care The New England Journal of Medicine. ,vol. 340, pp. 409- 417 ,(1999) , 10.1056/NEJM199902113400601
Ramachandran S Vasan, Martin G Larson, ScD, Emelia J Benjamin, Jane C Evans, Craig K Reiss, Daniel Levy, Congestive heart failure in subjects with normal versus reduced left ventricular ejection fraction: prevalence and mortality in a population-based cohort. Journal of the American College of Cardiology. ,vol. 33, pp. 1948- 1955 ,(1999) , 10.1016/S0735-1097(99)00118-7
Anatole Besarab, Managing anemia in patients with chronic heart failure: what do we know? Vascular Health and Risk Management. ,vol. 6, pp. 237- 252 ,(2010) , 10.2147/VHRM.S4619
Alberto Palazzuoli, Donald Silverberg, Francesca Iovine, Stefano Capobianco, Giovanna Giannotti, Anna Calabrò, Stella Maria Campagna, Ranuccio Nuti, Erythropoietin improves anemia exercise tolerance and renal function and reduces B-type natriuretic peptide and hospitalization in patients with heart failure and anemia. American Heart Journal. ,vol. 152, pp. 1096- 1099 ,(2006) , 10.1016/J.AHJ.2006.08.005
Luis E. Rohde, Nadine Clausell, Luis Beck da Silva, Etiology and Management of Anemia in Patients With Heart Failure : How Much Iron Is Missing? Congestive Heart Failure. ,vol. 14, pp. 25- 30 ,(2008) , 10.1111/J.1751-7133.2008.07394.X
Inder Anand, John J.V. McMurray, James Whitmore, Marshelle Warren, Anh Pham, Mark A. McCamish, Paul B.J. Burton, Anemia and Its Relationship to Clinical Outcome in Heart Failure Circulation. ,vol. 110, pp. 149- 154 ,(2004) , 10.1161/01.CIR.0000134279.79571.73
Christine K Choy, Anne P Spencer, Jean M Nappi, Prevalence of anemia in clinic patients with heart failure and cost analysis of epoetin treatment. Pharmacotherapy. ,vol. 27, pp. 707- 714 ,(2007) , 10.1592/PHCO.27.5.707
G Michael Felker, Wendy A Gattis, Jeffrey D Leimberger, Kirkwood F Adams, Michael S Cuffe, Mihai Gheorghiade, Christopher M O'Connor, None, Usefulness of anemia as a predictor of death and rehospitalization in patients with decompensated heart failure The American Journal of Cardiology. ,vol. 92, pp. 625- 628 ,(2003) , 10.1016/S0002-9149(03)00740-9
Rakesh Sharma, Darrel P Francis, Bertram Pitt, Philip A Poole-Wilson, Andrew JS Coats, Stefan D Anker, Haemoglobin predicts survival in patients with chronic heart failure: a substudy of the ELITE II trial European Heart Journal. ,vol. 25, pp. 1021- 1028 ,(2004) , 10.1016/J.EHJ.2004.04.023