Amplification of enantiomeric excess, mirror-image symmetry breaking and kinetic proofreading in Soai reaction models with different oligomeric orders

摘要: A comprehensive kinetic analysis of three prototypical autocatalytic cycle models based on the absolute asymmetric Soai reaction is presented. The models, which can give rise to amplification enantiomeric excess and mirror-image symmetry breaking, vary by their monomeric, dimeric or trimeric order assumed catalytic species. Our numerical approach considered entire chiral combinatorics diastereomeric interactions in as well multiplicity coupled reversible reactions without applying fast equilibration quasi-steady state approximations. For simplest monomeric model, an extensive range parameters was explored employing a random grid parameter scanning method that revealed influence values product distribution, reaction-time, attenuation presence absence breaking. breaking test imposed showing increase oligomer size from one leads higher tolerance poorer recognition between diastereoisomers identifies greater impact diastereoisomeric energy difference over imperfect stereoselectivity step. This robustness understood particular case so-called proofreading autocatalysis.