Prenatal immobilization stress and postnatal maternal separation cause differential neuroendocrine responses to fasting stress in adult male rats.

摘要: Prenatal immobilization stress (PNS) and postnatal maternal separation (MS180) are two widely used rodent models of early-life (ELS) that affect the hypothalamus-pituitary-adrenal (HPA) axis, cause behavioral alterations, glucose tolerance in adults. We compared anxiety-like behavior, coping strategies, HPA axis activity PNS MS180 adult (4-month-old) male rats assessed their response after mild fasting stress. Both induced a passive strategy forced swimming test, without affecting behavior elevated plus-maze. Moreover, both increased hypothalamic corticotropin-releasing hormone expression; however, only circulating corticosterone levels. early life stressors levels this effect was significantly higher rats. showed impaired 120 min intravenous administration, whereas displayed an efficient homeostatic response. corticosteroid to (overnight fasting, 12 hr), which were restored administration. In conclusion, exposure MS180, unlike PNS, increases moderate stress, indicating differential perception as stressor these ELS models.