Elimination of ephedrines in urine following multiple dosing: the consequences for athletes, in relation to doping control

摘要: Aims  To study the elimination of ephedrines with reference to International Olympic Committee (IOC) doping control cut-off levels, following multiple dosing over-the-counter decongestant preparations. Methods  A double-blind was performed in which 16 healthy male volunteers were administered either pseudoephedrine or phenylpropanolamine maximal recommended therapeutic doses over a 36-h period. Urine collected every two hours between 08:00 and 24:00 h at 04:00 h throughout testing period three days. drug levels quantified using high performance liquid chromatography. Side-effects assessed, including heart rate blood pressure, four 20:00 h. Results  Mean (95% CI) total eliminated unchanged 75 (88, 61) 81 (92, 71)%, respectively. Maximum urine concentrations 112.1 (164.2, 59.9) 148.5 (215.0, 82.1) mg.l−1, peak concentration occurred final dose. There no adverse cardiovascular effects only mild CNS stimulation evident. Conclusions  Following therapeutic, dosing, remain above IOC for minimum 6 h 16 h pseudoephedrine, Athletes require informed advice on this from their healthcare professionals.