EFFECTS ON THE HUMAN CENTRAL NERVOUS SYSTEM OF TWO ISOMERS OF EPHEDRINE AND TRIPROLIDINE, AND THEIR INTERACTION

摘要: 1 D(-)ephedrine is four times as potent L(+)pseudoephedrine in producing both tachycardia and a rise systolic blood pressure. No changes diastolic pressure occurred 12 subjects with doses of up to (50 mg) (180 mg). 2 Significant evidence stimulation the central nervous system only after that tapping rates were increased could reliably detect they had received an active drug. While mean performance auditory vigilance test higher following ephedrine isomers these not significant. 3 Impairment triprolidine another group subjects. The effect was generally related dose antihistamine given lasted 7.25 hours. Subjective effects recognized by all treatments containing (2.5 mg or more) for 4.75 Using analogue lines self rating subjective indicated mental physical impairment differing significantly from scores lactose (60 mg). 4 Combination produced similar alone on measures test. It suggested objective tests scales be used measure antihistamines together drugs, their interaction other compounds administered concurrently.