Histaminergic systems and sleep. Studies in man with H1 and H2 antagonists.

摘要: Abstract Effects of H1 (mepyramine, mequitazine, triprolidine and brompheniramine) H2 (cimetidine ranitidine) antagonists on sleep were studied in healthy man. There no effects mepyramine (50 100mg), the only effect mequitazine (5 10mg) was a reduction number awakenings. Triprolidine (10 20 mg) brompheniramine (4 8mg) did not alter wakefulness during or total time, but rapid eye movement reduced. ranitidine (150 300 mg), slow wave increased by cimetidine (200 400 mg). It is tentatively suggested that histaminergic system concerned with mechanisms which favour vigilance wakeful state, balance between activity sleep. some antihistamines are believed to be due their monoaminergic rather than activity.