Histamine H1 Receptor Antagonists in the Treatment of Insomnia

摘要: Neuroanatomical, neurochemical and neuropharmacological studies support a role for histamine in the control of waking state. In this respect, H1 receptor plays predominant role. Acute administration first-generation antagonists [chlorphenamine (chlorpheniramine), diphenhydramine, mepyramine (pyrilamine) triprolidine] produces somnolence, an increased likelihood falling asleep reduced concentration. These effects led to use these drugs as over-the-counter medications promote sleep. The widespread sedative antihistamines sleep aids stems from inappropriate attempts by undiagnosed untreated patients with insomnia resolve their disturbance.