Substituting Walnuts for Monounsaturated Fat Improves the Serum Lipid Profile of Hypercholesterolemic Men and Women

摘要: Background: It has been reported that walnuts reduce serum cholesterol levels in normal young men. Objective: To assess the acceptability of and their effects on lipid low-density lipoprotein (LDL) oxidizability free-living hypercholesterolemic persons. Design: Randomized, crossover feeding trial. Setting: Lipid clinic at a university hospital. Patients: 55 men women (mean age, 56 years) with polygenic hypercholesterolemia. Intervention: A cholesterol-lowering Mediterranean diet similar energy fat content which replaced approximately 35% obtained from monounsaturated fat. Patients followed each for 6 weeks. Measurements: Low-density fatty acids (to compliance), levels, lipoprotein(a) LDL resistance to vitro oxidative stress. Results: 49 persons completed The walnut was well tolerated. Planned observed diets were closely matched. Compared diet, produced mean changes -4.1% total level, -5.9% -6.2% level. differences -0.28 mmol/L (95% Cl, -0.43 -0.12 mmol/L) (-10.8 mg/dL [-16.8 -4.8 mg/dL]) (P < 0.001) -0.29 (Cl, -0.41 -0.15 (-11.2 [-16.3 -6.1 -0.021 g/L -0.042 -0.001 g/L) = 0.042) except decreased only particles enriched polyunsaturated walnuts, but oxidation preserved. Conclusion: Substituting part further reduced