Cerebrospinal fluid concentrations of aqueous procaine penicillin G in the neonate

摘要: Simultaneous serum and CSF samples were obtained following the intramuscular administration of 50,000 units/kg aqueous procaine penicillin G in 25 neonates. Penicillin activity was detected sera all patients. Peak levels noted at four hours (mean +/- SEM, 17.1 6.3 micrograms/ml). 12 (0.70 0.35 microgram/ml). The level 24 2.1 0.98 microgram/ml (range, 0.2 to 5.8 micrograms/ml); 0.12 0.05 micrograms/ml 0.03 0.27 These results demonstrate that spirocheticidal (greater than or equal microgram/ml) are achieved for least