Survival of treponemes after treatment: comments, clinical conclusions, and recommendations.

作者: E M Dunlop

DOI: 10.1136/STI.61.5.293

关键词: MedicineSurgeryPenicillinPenicillin G BenzathineCefuroximePenicillin G ProcaineProcaineSyphilisNeurosyphilisDermatologyErythromycin

摘要: Treponemes may persist after treatment that has been accepted as effective; the reasons for this are discussed. Nevertheless, epidemic of syphilis second world war was not followed by an late syphilis, and results with penicillin excellent. Neurological signs progress in some treated patients, standard doses soluble any dose benzathine (even added probenecid mouth) cannot be relied on to achieve treponemicidal concentrations cerebrospinal fluid (CSF). There no large scale studies CSF findings early penicillin. Standard dosage, such procaine G 600 000 international units (IU) intramuscular injection 10 days, is choice patient suffering from uncomplicated syphilis; should preferred penicillin, which only used when above given. Treponemicidal achieved patients neurosyphilis schedules mouth single daily injections; last 17 21 days. Benzathine or iritis including accompanying interstitial keratitis. Treatment keratitis initially neurosyphilis, but recurrent cases it have prolonged eradicate Treponema pallidum dividing slowly. Doxycycline 200 mg days provides a supervisable outpatient schedule allergic Cephaloridine (and probably cefuroxime new cephalosporins) useful who developed anaphylactic allergy. If erythromycin treating pregnant women then newborn babies

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