Short-term, high-dose glucocorticoid treatment does not contribute to reduced bone mineral density in patients with multiple sclerosis

摘要: Background: Patients with multiple sclerosis (MS) are at increased risk of reduced bone mineral density (BMD). A contributing factor might be treatment high-dose glucocorticoids (GCs). Objectives: The objective this paper is to assess mass in patients MS and evaluate the importance short-term, GC other factors that affect BMD MS. Methods: total 260 received short-term had their measured by dual x-ray absorptiometry. was compared a healthy age-matched reference population (Z-scores). Data regarding GCs, age, body index (BMI), serum 25(OH)D, disease duration severity were collected retrospectively analysed linear regression analysis association between each BMD. Results: Osteopenia present 38% osteoporosis 7% study population. Mean Z-score significantly below zero, indicating decreased our patients. Multiple showed no significant GCs In contrast, BMI independently associated both lumbar femoral Conclusion: Reduced prevalent appears not primary underlying cause secondary