Impact of BRCA1/2 mutation on young women's 5-year parenthood rates: a prospective comparative study (GENEPSO-PS cohort).

摘要: Previous qualitative and intentions surveys have shown that the disclosure of a BRCA1/2 mutation might deter young women from becoming pregnant. However, to our knowledge, no comparative studies ever documented possibility positive genetic test results affect these women’s future reproductive rates. Our aim was therefore quantify impact on long-term relationships between partners childbearing Participants were cancer-free belonging families in which deleterious had been identified, who attended one 29 participating cancer clinics for testing 2000 2006. Logistic regression models used determine predictors 5-year self-reported parenthood rate. The sample consisted 271 aged 18–45 years (126 carriers 145 non-carriers). Couples separated more frequently among than non-carriers (10 vs. 3 %, p = .040), especially nulliparous (13 %). Among 104 childless at disclosure, not significantly associated with during follow-up period [adjusted odds ratio .64, 95 % confidence interval (CI) (.26, 1.57), p = .334]. 167 least child conspicuous effect trends [adjOR .88, CI (.35, 2.21), p = .787]. couples’ mothering rates, particularly women. Studies larger populations are now required confirm findings.