Lipid Second Messengers
作者： Robert M Bell , John H Exton , Stephen M Prescott
DOI: 10.1007/978-1-4899-1813-0_63
关键词:
摘要: Phospholipids represent a complex and structurally diverse class of molecules serving multiple critical functions within cells. In addition to as structural components membranes, phospholipids act reservoirs for the generation bioactive lipids which function in signal transduction pathways regulating cell behavior including growth, differentiation, apoptosis1. Understanding these has increased dramatically over last 10 years spite rapid interconversion extensive crosstalk among signalling pathways. Bioactive bind regulate elements pathways, eg. DAG/protein kinase C. Our studies demonstrate that phosphatidic acid binds carboxy terminus region protooncogene Raf-1 suggesting PA may influence association with membrane thus activation enzyme2. This is concordance previous have shown many same agonists stimulate PC-specific phospholipase D lead activation. Addtionally, results are agreement observation stimulates mitogenesis.
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sci-hub.st 参考文章(29)
Xian-Feng Zhang, Jeffrey Settleman, John Kyriakis, Erika Takeuchi-Suzuki, Stephen J Elledge, Mark S Marshall, Joseph T Bruder, Ulf R Rapp, Joseph Avruch, None, Normal and oncogenic p21ras proteins bind to the amino-terminal regulatory domain of c-Raf-1. Nature. ,vol. 364, pp. 308- 313 ,(1993) , 10.1038/364308A0
S. Moodie, B. Willumsen, M. Weber, A Wolfman, Complexes of Ras.GTP with Raf-1 and mitogen-activated protein kinase kinase Science. ,vol. 260, pp. 1658- 1661 ,(1993) , 10.1126/SCIENCE.8503013
Jeffrey W. Orr, Alexandra C. Newton, Interaction of protein kinase C with phosphatidylserine. 1. Cooperativity in lipid binding Biochemistry. ,vol. 31, pp. 4661- 4667 ,(1992) , 10.1021/BI00134A018
Mordechai Liscovitch, Crosstalk among multiple signal-activated phospholipases Trends in Biochemical Sciences. ,vol. 17, pp. 393- 399 ,(1992) , 10.1016/0968-0004(92)90007-V
D Stokoe, S. Macdonald, K Cadwallader, M Symons, J. Hancock, Activation of Raf as a result of recruitment to the plasma membrane Science. ,vol. 264, pp. 1463- 1467 ,(1994) , 10.1126/SCIENCE.7811320
H. Koide, T. Satoh, M. Nakafuku, Y. Kaziro, GTP-dependent association of Raf-1 with Ha-Ras: identification of Raf as a target downstream of Ras in mammalian cells. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 90, pp. 8683- 8686 ,(1993) , 10.1073/PNAS.90.18.8683
W Matten, I Daar, G F Vande Woude, PROTEIN KINASE A ACTS AT MULTIPLE POINTS TO INHIBIT XENOPUS OOCYTE MATURATION Molecular and Cellular Biology. ,vol. 14, pp. 4419- 4426 ,(1994) , 10.1128/MCB.14.7.4419
Rapp Ur, Role of Raf-1 serine/threonine protein kinase in growth factor signal transduction. Oncogene. ,vol. 6, pp. 495- 500 ,(1991)
C Huang, R.L. Wykle, L.W. Daniel, M.C. Cabot, Identification of Phosphatidylcholine-selective and Phosphatidylinositol-selective Phospholipases D in Madin-Darby Canine Kidney Cells* Journal of Biological Chemistry. ,vol. 267, pp. 16859- 16865 ,(1992) , 10.1016/S0021-9258(18)41863-7
U.R. Rapp, J.V. Bonventre, J. Avruch, J.M. Kyriakis, T.L. Force, Mitogen regulation of c-Raf-1 protein kinase activity toward mitogen-activated protein kinase-kinase. Journal of Biological Chemistry. ,vol. 268, pp. 16009- 16019 ,(1993) , 10.1016/S0021-9258(18)82351-1