Cytokines as determinants of resistance and pathology in human Schistosoma mansoni infection

摘要: The role of different cytokines in the peripheral blood mononuclear cell (PBMC) proliferative response and vitro granuloma formation was evaluated a cross-sectional study with patients clinical forms phases Schistosoma mansoni infection, as well group individuals "naturally" resistant to infection named normal endemic (NE). blockage IL-4 IL-5 using anti-IL-4 anti-IL-5 antibodies significantly reduced PBMC soluble egg (SEA) adult worm (SWAP) antigens acute (ACT), chronic intestinal (INT) hepatosplenic (HS) patients. Similar results were obtained formation. Blockage IL-10 had no significant effect on either assay from ACT or HS. In contrast, addition anti-IL-10 cultures INT increased SEA SWAP Interestingly, association did not increase these patients, suggesting that may act by modulating secretion. Addition recombinant decreased undetectable levels when used. Analysis IFN-g supernatants showed secreted low upon antigenic stimulation. NE high IFN-g. These data suggest is an important cytokine regulating immune possibly controlling morbidity human schistosomiasis mansoni, production be associated resistance infection.