Further dissection of the functional heterogeneity within the OKT4+ and OKT8+ human T cell subsets.

摘要: Previous studies have suggested functional heterogeneity within the OKT4+ and OKT8+ populations. For example, after activation population contains not only helper cells but also capable of suppressing B cell differentiation. indicate that reciprocal T population, OKT8+, does provide activity cytotoxic effector radiosensitive important in suppression Using a new differentiation antigen, OKT17, which recognizes surface antigen present on majority resting normal peripheral lymphocytes is subset activation, evidence was obtained two functionally mature subsets can be distinguished itself: OKT4+17+ suppressor OKT4+17- cells. Recently, another monoclonal antibody, OKT20, has been described small percentage expressed varying proportions activated Functional analysis human demonstrated OKT20-depleted able to generate suppress antibody production same extent as did On other hand, when unselected were cultured for six days mixed lymphocyte reaction then depleted OKT20 reactive cells, eliminated. In contrast, identical still production. These data following becomes selectively effectors