Candidate counterparts of sezary cells and adult T-cell lymphoma-leukaemia cells in normal peripheral blood: An ultrastructural study with the immunogold method and monoclonal antibodies
作者： Estela Matutes , Daniele Robinson , Maureen O'Brien , Barton F. Haynes , Heddy Zola
DOI: 10.1016/0145-2126(83)90073-5
关键词:
摘要: The ultrastructural and immunologic features of normal convoluted T-lymphocytes were studied with a panel monoclonal antibodies the immunogold technique these compared cells from patients Sezary syndrome (SS) adult T-cell lymphoma-leukaemia (ATLL). According to characteristics nucleus, two distinct subtypes, representing 2-4% peripheral blood lymphocytes recognized: (i) cerebriform lymphocyte ('Sezary-like') characterized by narrow deep nuclear indentations, closely resembling SS, (ii) or polylobated ('ATLL-like'), shorter broader indentations than those seen in that resemble ATLL. Both types positive OKT3, OKT4, OKT17 FMC3 negative OKT8, OKM1 FMC4 (anti-HLA-Dr) as SS ATLL cells. A difference was observed expression anti-T antibody 3Al: Sezary-like lymphocytes, like cells, 3Al whilst ATLL-like positive. close morphological membrane phenotype similarities between suggest they may well represent counterparts malignant T both conditions.
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