Cisplatin ototoxicity, increased DPOAE amplitudes, and magnesium deficiency. Distortion product otoacoustic emissions.
作者： M J Cevette , D Drew , T M Webb , M S Marion
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摘要: Outer hair cell (OHC) metabolism is blocked by cisplatin. Concurrent changes in the renal handling of magnesium occur because damage cisplatin causes to proximal tubule cells within thick ascending loop Henle. Although there no evidence OHCs, are significant levels intracellular calcium, antagonist at membrane. The OHC motile response dependent on calcium. When calcium current suppressed an antagonist, extracellular microphonic potential decreases. Magnesium deficiency known produce hyperexcitability central nervous system, including fatal audiogenic seizures. In addition, increases amplitude auditory brainstem wave V with aminoglycoside therapy and deficiency. This paper illustrates growth distortion product otoacoustic emissions two patients treated explores possible underlying reasons why this may be related metabolism.
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