Declines in levels of hyperpolarization-activated cation (HCN) channels in the rat ovary after cisplatin exposure.
作者： John Yeh , Beom Su Kim , Jennifer Peresie , Carly Page
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摘要: The distribution of the 4 hyperpolarization-activated cation (hyperpolarization-activated, cyclic nucleotide-gated [HCN]) channels (HCN1-4), associated with rhythmic electrical bursting, varies in different cells ovary. Cisplatin is a broadly used chemotherapeutic agent that results ovarian damage. objective this study was to test hypothesis cisplatin treatment will affect expression HCN channels. Adult female Sprague-Dawley rats were dosed saline, 4.5 mg/kg cisplatin, or 6.0 as 2 weekly injections and then killed 5 days after second dose. ovaries studied for HCN1-4 using semiquantitative H score immunohistochemical analysis Western blot analysis. By immunohistochemistry, HCN4, oocyte-specific staining declined (P < .001). There decline HCN2 intensity antral granulosa .05) thecal .05). no differences found HCN1 HCN3 scores cisplatin. revealed there levels exposure For HCN2, change total protein Treatment vivo resulted rat ovary, oocytes, cells, being specifically affected.
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