Inducing host protection in pneumococcal sepsis by preactivation of the Ashwell-Morell receptor
作者： P. K. Grewal , P. V. Aziz , S. Uchiyama , G. R. Rubio , R. D. Lardone
关键词:
摘要: The endocytic Ashwell-Morell receptor (AMR) of hepatocytes detects pathogen remodeling host glycoproteins by neuraminidase in the bloodstream and mitigates lethal coagulopathy sepsis. We have investigated mechanism protection AMR during onset sepsis response to desialylation blood NanA Streptococcus pneumoniae. find that selects among potential glycoprotein ligands unmasked microbial activity pneumococcal eliminate from circulation factors contribute coagulation thrombosis. This is attributable large part rapid induction a moderate thrombocytopenia AMR. further show can be manipulated induce clearance including platelets, thereby preactivating protective moderates severity disseminated intravascular enables survival.
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