Impact of oxidative stress on male and female germ cells: implications for fertility

摘要: Male and female germ lines are vulnerable to oxidative stress. In spermatozoa, such stress triggers a lipid peroxidation cascade that culminates in the generation of electrophilic aldehydes bind DNA raft proteins involved delivery functionally competent cells. One set targets for these mitochondrial electron transport chain. When this interaction occurs, ROS is enhanced leading sustained damage self-perpetuating cycle. Such affects all aspects sperm function including motility, sperm-egg recognition, acrosomal exocytosis sperm-oocyte fusion. Oxidative male line also attacks integrity with potential impacts on developmental capacity embryos health wellbeing offspring. Potential pathways reactive oxygen species (ROS) cells could involve lipoxygenase activity, activation NADPH oxidase and/or leakage from mitochondria. Similarly, line, both induction oocyte senescence following ovulation deterioration quality maternal age appear damage. case, mitochondria be particularly important source compromising viability fertilizability interfering normal segregation chromosomes during meiosis. light considerations, antioxidants should have some role play preservation reproductive men women; however, we still await appropriate trials test hypothesis.