作者: Laura K Thomson , Steven D Fleming , R John Aitken , Geoffry N De Iuliis , J-A Zieschang
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摘要: results: Cryopreservation led to a significant increase in percentage DNA fragmentation, 8OHdG and caspase positive cells (P , 0.001). Percentage fragmentation was positively correlated with before (r ¼ 0.756, P 0.001) after cryopreservation 0.528, 0.017). The addition of 50 100 mM genistein the cryoprotectant had protective effect on sperm although inhibitor demonstrated no difference control. conclusions: Human is associated an oxidative stress during cryopreservation, rather than activation caspases apoptosis. estrogenic compound may be useful reducing this but larger trials are needed confirm this.