Efficacy of Rifampin-Moxifloxacin-Metronidazole Combination Therapy in Hidradenitis Suppurativa

摘要: Background: Antibiotics have been shown to improve hidradenitis suppurativa (HS) patients but complete remission is rare using these treatments. Objective: To assess the efficacy and safety of a combination oral rifampin, moxifloxacin metronidazole in long-lasting refractory HS. Methods: We retrospectively studied 28 consecutive HS including 6, 10 12 Hurley stage 1, 2 3 patients, respectively. Complete remission, defined as clearance all inflammatory lesions hypertrophic scars, was main outcome criterion study. Results: obtained 16 6/6, 8/10 2/12 with 3, respectively (p = 0.0004). The median duration treatment obtain 2.4 (range 0.9–6.5) 3.8 months 1.6–7.4) 1 respectively, 6.2 patients. Main adverse events treatments were gastrointestinal disorders (64% patients) vaginal candidiasis (35% females). Reversible tendinopathy hepatitis occurred 4 patient, Conclusions: can be broad-spectrum antibiotics staging prognostic factor response treatment.